Large K + intake results in accumulation out of K + from the interstitium of one’s kidney due to medullary recycling cleanup. Old education suggested that the upsurge in interstitial K + quantity would end in an enthusiastic inhibitory effect on salt transport inside the the brand new thicker ascending limb and you will proximal tubule, which do end up in increased Na + and you will liquid birth into the distal nephron, allowing for improved K + secretion (six, 53, 54). As chatted about below, present studies have worried about just how K + intake modulates transport on reasonable-potential early distal convoluted tubule (DCT) in order to to change tubular flow so you can K + secretory internet. These studies recommend that the outcome out-of dietary K + so you’re able to modulate move and beginning away from Na + to K + secretory internet sites is far more regionalized and you will restricted toward down capability distal nephron.
New resulting upsurge in Na + birth and you can disperse including improved aldosterone facilitates electrogenic K + hormonal owing to ROMK
The latest DCT constitutes an excellent proximal part (DCT1) and you may a distal section (DCT2). On DCT1, salt transport are inspired entirely by the thiazide-painful and sensitive NaCl cotransporter (NCC), while in the DCT2, electroneutral NaCl transportation coexists which have electrogenic Na + and you will K + transportation routes (28). On DCT2, aldosterone sensitiveness, that’s important to support K + homeostasis, initiate and you will gets to new event duct. Cells of one’s early DCT exert a substantial, albeit indirect, role into the K + secretion recommended by proven fact that alterations in transportation regarding the early DCT manage the new beginning out of NaCl to the downstream linking tubule and you will colleting duct, the spot where the epithelial sodium channel (ENaC) mediates electrogenic Na + reabsorption and in which K + are secreted (Fig. 3).
Fig. step three.Older training (six, 53, 54) has recommended you to restoration off K + homeostasis regarding means off large K + weight loss intake is actually set off by a keen inhibitory effect of K + towards Na + reabsorption on heavy rising limb and you may proximal tubule of your own kidney, and thus facilitating increased delivery away from Na + to servings of your https://datingranking.net/feeld-review/ own distal nephron tuned in to mineralocorticoid passion. Present findings recommend that this course of action is more regionalized and you will implicate the fresh new distal convoluted tubule (DCT) as the a kidney K + sensor. High K + intake suppress electroneutral NaCl transportation on proximal part of the distal convoluted tubule (DCT1). Aldosterone and you may circulate may also increase K + hormonal via the Maxi-K route. Improved secretion will be started up on K + admission on the gastrointestinal tract using an enteric K + -sensing procedure you to definitely suppress Na + -Cl ? cotransporter (NCC) craft throughout the absence of change in plasma quantity.
ENaC, epithelial sodium route; Video game, meeting duct
The spot of your DCT1 immediately upstream in the aldosterone-delicate distal nephron (ASDN) and its reasonable capability character make this part a very likely web site to own changes in diet K + consumption to regulate Na + transportation and make certain that downstream delivery away from Na + is exactly extent had a need to ensure fix regarding K + homeostasis without producing undesireable effects into the frequency. Weight-loss consumption of K + , which causes changes in plasma K + amount, results in an inhibitory impact on NCC craft. Because of this, Na + beginning and you may disperse is increased to new aldosterone delicate K + secretory places found in the later servings of your own DCT (DCT2) and meeting duct. At the same time, the rise in the plasma K + attention following intake generates aldosterone release on the adrenal gland, which in turn facilitates electrogenic K + hormonal due to ROMK. Each other improved flow and you can aldosterone turn on K + secretion from Maxi-K station (15, 28).